Partitioning with 1000G LD scores on HapMap3 SNPs with Human_Striatum_snATAC.mergedReg2Map bed regions making annot file Computing partitioned LD scores for hg38 for EUR. ********************************************************************* * LD Score Regression (LDSC) * Version 1.0.1 * (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane * Broad Institute of MIT and Harvard / MIT Department of Mathematics * GNU General Public License v3 ********************************************************************* Call: ./ldsc.py \ --print-snps /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt \ --out /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.mergedReg2Map.EUR.7 \ --bfile /tmp/ldsc-2024-06-24-VdNGxFmT1A/1000G.EUR.HM3.7 \ --thin-annot \ --annot /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.mergedReg2Map.EUR.7.annot.gz \ --l2 \ --ld-wind-kb 1000.0 Beginning analysis at Mon Jun 24 14:11:57 2024 Read list of 66700 SNPs from /tmp/ldsc-2024-06-24-VdNGxFmT1A/1000G.EUR.HM3.7.bim Read 1 annotations for 66700 SNPs from /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.mergedReg2Map.EUR.7.annot.gz Read list of 503 individuals from /tmp/ldsc-2024-06-24-VdNGxFmT1A/1000G.EUR.HM3.7.fam Reading genotypes from /tmp/ldsc-2024-06-24-VdNGxFmT1A/1000G.EUR.HM3.7.bed After filtering, 66700 SNPs remain Estimating LD Score. Reading list of 1215001 SNPs for which to print LD Scores from /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt After merging with --print-snps, LD Scores for 66700 SNPs will be printed. Writing LD Scores for 66700 SNPs to /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.mergedReg2Map.EUR.7.l2.ldscore.gz Summary of LD Scores in /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.mergedReg2Map.EUR.7.l2.ldscore.gz MAF L2 mean 0.2374 3.1204 std 0.1437 3.2182 min 0.0020 -0.2089 25% 0.1111 0.9519 50% 0.2276 2.1441 75% 0.3608 4.1625 max 0.5000 25.7526 MAF/LD Score Correlation Matrix MAF L2 MAF 1.0000 0.2224 L2 0.2224 1.0000 Annotation Correlation Matrix ANNOT ANNOT 1.0 Annotation Matrix Column Sums ANNOT 10778 Summary of Annotation Matrix Row Sums count 66700.0000 mean 0.1616 std 0.3681 min 0.0000 25% 0.0000 50% 0.0000 75% 0.0000 max 1.0000 Analysis finished at Mon Jun 24 14:14:09 2024 Total time elapsed: 2.0m:12.16s Done.