Partitioning with 1000G LD scores on HapMap3 SNPs with Human_Striatum_snATAC.mergedReg2Map bed regions making annot file Computing partitioned LD scores for hg38 for EUR. ********************************************************************* * LD Score Regression (LDSC) * Version 1.0.1 * (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane * Broad Institute of MIT and Harvard / MIT Department of Mathematics * GNU General Public License v3 ********************************************************************* Call: ./ldsc.py \ --print-snps /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt \ --out /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.mergedReg2Map.EUR.13 \ --bfile /tmp/ldsc-2024-06-24-8cFt4hN3p2/1000G.EUR.HM3.13 \ --thin-annot \ --annot /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.mergedReg2Map.EUR.13.annot.gz \ --l2 \ --ld-wind-kb 1000.0 Beginning analysis at Mon Jun 24 14:11:57 2024 Read list of 45938 SNPs from /tmp/ldsc-2024-06-24-8cFt4hN3p2/1000G.EUR.HM3.13.bim Read 1 annotations for 45938 SNPs from /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.mergedReg2Map.EUR.13.annot.gz Read list of 503 individuals from /tmp/ldsc-2024-06-24-8cFt4hN3p2/1000G.EUR.HM3.13.fam Reading genotypes from /tmp/ldsc-2024-06-24-8cFt4hN3p2/1000G.EUR.HM3.13.bed After filtering, 45938 SNPs remain Estimating LD Score. Reading list of 1215001 SNPs for which to print LD Scores from /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt After merging with --print-snps, LD Scores for 45938 SNPs will be printed. Writing LD Scores for 45938 SNPs to /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.mergedReg2Map.EUR.13.l2.ldscore.gz Summary of LD Scores in /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.mergedReg2Map.EUR.13.l2.ldscore.gz MAF L2 mean 0.2321 2.4906 std 0.1437 2.5526 min 0.0020 -0.1577 25% 0.1054 0.6976 50% 0.2187 1.6510 75% 0.3539 3.4072 max 0.5000 19.2034 MAF/LD Score Correlation Matrix MAF L2 MAF 1.0000 0.2037 L2 0.2037 1.0000 Annotation Correlation Matrix ANNOT ANNOT 1.0 Annotation Matrix Column Sums ANNOT 6485 Summary of Annotation Matrix Row Sums count 45938.0000 mean 0.1412 std 0.3482 min 0.0000 25% 0.0000 50% 0.0000 75% 0.0000 max 1.0000 Analysis finished at Mon Jun 24 14:13:27 2024 Total time elapsed: 1.0m:30.1s Done.