Partitioning with 1000G LD scores on HapMap3 SNPs with Human_Striatum_snATAC.mergedReg2Map bed regions making annot file Computing partitioned LD scores for hg38 for EUR. ********************************************************************* * LD Score Regression (LDSC) * Version 1.0.1 * (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane * Broad Institute of MIT and Harvard / MIT Department of Mathematics * GNU General Public License v3 ********************************************************************* Call: ./ldsc.py \ --print-snps /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt \ --out /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.mergedReg2Map.EUR.10 \ --bfile /tmp/ldsc-2024-06-24-jd9f0lYruR/1000G.EUR.HM3.10 \ --thin-annot \ --annot /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.mergedReg2Map.EUR.10.annot.gz \ --l2 \ --ld-wind-kb 1000.0 Beginning analysis at Mon Jun 24 14:11:57 2024 Read list of 64659 SNPs from /tmp/ldsc-2024-06-24-jd9f0lYruR/1000G.EUR.HM3.10.bim Read 1 annotations for 64659 SNPs from /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.mergedReg2Map.EUR.10.annot.gz Read list of 503 individuals from /tmp/ldsc-2024-06-24-jd9f0lYruR/1000G.EUR.HM3.10.fam Reading genotypes from /tmp/ldsc-2024-06-24-jd9f0lYruR/1000G.EUR.HM3.10.bed After filtering, 64659 SNPs remain Estimating LD Score. Reading list of 1215001 SNPs for which to print LD Scores from /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt After merging with --print-snps, LD Scores for 64659 SNPs will be printed. Writing LD Scores for 64659 SNPs to /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.mergedReg2Map.EUR.10.l2.ldscore.gz Summary of LD Scores in /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.mergedReg2Map.EUR.10.l2.ldscore.gz MAF L2 mean 0.2309 3.0367 std 0.1435 3.3689 min 0.0020 -0.2261 25% 0.1054 0.8516 50% 0.2177 1.9931 75% 0.3529 3.9642 max 0.5000 30.2047 MAF/LD Score Correlation Matrix MAF L2 MAF 1.0000 0.2205 L2 0.2205 1.0000 Annotation Correlation Matrix ANNOT ANNOT 1.0 Annotation Matrix Column Sums ANNOT 9975 Summary of Annotation Matrix Row Sums count 64659.0000 mean 0.1543 std 0.3612 min 0.0000 25% 0.0000 50% 0.0000 75% 0.0000 max 1.0000 Analysis finished at Mon Jun 24 14:14:06 2024 Total time elapsed: 2.0m:8.44s Done.