Partitioning with 1000G LD scores on HapMap3 SNPs with Human_Striatum_snATAC.mergedReg2Map bed regions making annot file Computing partitioned LD scores for hg38 for AFR. ********************************************************************* * LD Score Regression (LDSC) * Version 1.0.1 * (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane * Broad Institute of MIT and Harvard / MIT Department of Mathematics * GNU General Public License v3 ********************************************************************* Call: ./ldsc.py \ --print-snps /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt \ --out /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.mergedReg2Map.AFR.6 \ --bfile /tmp/ldsc-2024-06-24-qTn2SsBqZS/1000G.AFR.HM3.6 \ --thin-annot \ --annot /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.mergedReg2Map.AFR.6.annot.gz \ --l2 \ --ld-wind-kb 1000.0 Beginning analysis at Mon Jun 24 14:11:57 2024 Read list of 73528 SNPs from /tmp/ldsc-2024-06-24-qTn2SsBqZS/1000G.AFR.HM3.6.bim Read 1 annotations for 73528 SNPs from /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.mergedReg2Map.AFR.6.annot.gz Read list of 661 individuals from /tmp/ldsc-2024-06-24-qTn2SsBqZS/1000G.AFR.HM3.6.fam Reading genotypes from /tmp/ldsc-2024-06-24-qTn2SsBqZS/1000G.AFR.HM3.6.bed After filtering, 73528 SNPs remain Estimating LD Score. Reading list of 1215001 SNPs for which to print LD Scores from /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt After merging with --print-snps, LD Scores for 73528 SNPs will be printed. Writing LD Scores for 73528 SNPs to /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.mergedReg2Map.AFR.6.l2.ldscore.gz Summary of LD Scores in /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.mergedReg2Map.AFR.6.l2.ldscore.gz MAF L2 mean 0.2216 1.6428 std 0.1455 1.6414 min 0.0015 -0.1047 25% 0.0953 0.5251 50% 0.2095 1.1450 75% 0.3419 2.1572 max 0.5000 14.8374 MAF/LD Score Correlation Matrix MAF L2 MAF 1.000 0.146 L2 0.146 1.000 Annotation Correlation Matrix ANNOT ANNOT 1.0 Annotation Matrix Column Sums ANNOT 11326 Summary of Annotation Matrix Row Sums count 73528.000 mean 0.154 std 0.361 min 0.000 25% 0.000 50% 0.000 75% 0.000 max 1.000 Analysis finished at Mon Jun 24 14:14:39 2024 Total time elapsed: 2.0m:41.9s Done.