Partitioning with 1000G LD scores on HapMap3 SNPs with Human_Striatum_snATAC.mergedReg2Map bed regions making annot file Computing partitioned LD scores for hg38 for AFR. ********************************************************************* * LD Score Regression (LDSC) * Version 1.0.1 * (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane * Broad Institute of MIT and Harvard / MIT Department of Mathematics * GNU General Public License v3 ********************************************************************* Call: ./ldsc.py \ --print-snps /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt \ --out /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.mergedReg2Map.AFR.4 \ --bfile /tmp/ldsc-2024-06-24-xMgdMQa5g5/1000G.AFR.HM3.4 \ --thin-annot \ --annot /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.mergedReg2Map.AFR.4.annot.gz \ --l2 \ --ld-wind-kb 1000.0 Beginning analysis at Mon Jun 24 14:11:57 2024 Read list of 75316 SNPs from /tmp/ldsc-2024-06-24-xMgdMQa5g5/1000G.AFR.HM3.4.bim Read 1 annotations for 75316 SNPs from /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.mergedReg2Map.AFR.4.annot.gz Read list of 661 individuals from /tmp/ldsc-2024-06-24-xMgdMQa5g5/1000G.AFR.HM3.4.fam Reading genotypes from /tmp/ldsc-2024-06-24-xMgdMQa5g5/1000G.AFR.HM3.4.bed After filtering, 75316 SNPs remain Estimating LD Score. Reading list of 1215001 SNPs for which to print LD Scores from /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt After merging with --print-snps, LD Scores for 75316 SNPs will be printed. Writing LD Scores for 75316 SNPs to /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.mergedReg2Map.AFR.4.l2.ldscore.gz Summary of LD Scores in /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.mergedReg2Map.AFR.4.l2.ldscore.gz MAF L2 mean 0.2302 1.3854 std 0.1448 1.4566 min 0.0015 -0.0950 25% 0.1051 0.3817 50% 0.2194 0.9240 75% 0.3525 1.8632 max 0.5000 12.4491 MAF/LD Score Correlation Matrix MAF L2 MAF 1.0000 0.1386 L2 0.1386 1.0000 Annotation Correlation Matrix ANNOT ANNOT 1.0 Annotation Matrix Column Sums ANNOT 10114 Summary of Annotation Matrix Row Sums count 75316.0000 mean 0.1343 std 0.3410 min 0.0000 25% 0.0000 50% 0.0000 75% 0.0000 max 1.0000 Analysis finished at Mon Jun 24 14:14:44 2024 Total time elapsed: 2.0m:46.36s Done.