Partitioning with 1000G LD scores on HapMap3 SNPs with Human_Striatum_snATAC.mergedReg2Map bed regions making annot file Computing partitioned LD scores for hg38 for AFR. ********************************************************************* * LD Score Regression (LDSC) * Version 1.0.1 * (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane * Broad Institute of MIT and Harvard / MIT Department of Mathematics * GNU General Public License v3 ********************************************************************* Call: ./ldsc.py \ --print-snps /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt \ --out /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.mergedReg2Map.AFR.21 \ --bfile /tmp/ldsc-2024-06-24-vmkRPx7Ocm/1000G.AFR.HM3.21 \ --thin-annot \ --annot /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.mergedReg2Map.AFR.21.annot.gz \ --l2 \ --ld-wind-kb 1000.0 Beginning analysis at Mon Jun 24 14:11:57 2024 Read list of 17085 SNPs from /tmp/ldsc-2024-06-24-vmkRPx7Ocm/1000G.AFR.HM3.21.bim Read 1 annotations for 17085 SNPs from /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.mergedReg2Map.AFR.21.annot.gz Read list of 661 individuals from /tmp/ldsc-2024-06-24-vmkRPx7Ocm/1000G.AFR.HM3.21.fam Reading genotypes from /tmp/ldsc-2024-06-24-vmkRPx7Ocm/1000G.AFR.HM3.21.bed After filtering, 17085 SNPs remain Estimating LD Score. Reading list of 1215001 SNPs for which to print LD Scores from /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt After merging with --print-snps, LD Scores for 17085 SNPs will be printed. Writing LD Scores for 17085 SNPs to /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.mergedReg2Map.AFR.21.l2.ldscore.gz Summary of LD Scores in /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.mergedReg2Map.AFR.21.l2.ldscore.gz MAF L2 mean 0.2291 1.3192 std 0.1449 1.5299 min 0.0015 -0.0823 25% 0.1036 0.3091 50% 0.2194 0.7854 75% 0.3510 1.7651 max 0.5000 11.8944 MAF/LD Score Correlation Matrix MAF L2 MAF 1.0000 0.0974 L2 0.0974 1.0000 Annotation Correlation Matrix ANNOT ANNOT 1.0 Annotation Matrix Column Sums ANNOT 2509 Summary of Annotation Matrix Row Sums count 17085.0000 mean 0.1469 std 0.3540 min 0.0000 25% 0.0000 50% 0.0000 75% 0.0000 max 1.0000 Analysis finished at Mon Jun 24 14:12:37 2024 Total time elapsed: 39.85s Done.