Partitioning with 1000G LD scores on HapMap3 SNPs with Human_Striatum_snATAC.mergedReg2Map bed regions making annot file Computing partitioned LD scores for hg38 for AFR. ********************************************************************* * LD Score Regression (LDSC) * Version 1.0.1 * (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane * Broad Institute of MIT and Harvard / MIT Department of Mathematics * GNU General Public License v3 ********************************************************************* Call: ./ldsc.py \ --print-snps /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt \ --out /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.mergedReg2Map.AFR.16 \ --bfile /tmp/ldsc-2024-06-24-lkwISUAqN8/1000G.AFR.HM3.16 \ --thin-annot \ --annot /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.mergedReg2Map.AFR.16.annot.gz \ --l2 \ --ld-wind-kb 1000.0 Beginning analysis at Mon Jun 24 14:11:57 2024 Read list of 36606 SNPs from /tmp/ldsc-2024-06-24-lkwISUAqN8/1000G.AFR.HM3.16.bim Read 1 annotations for 36606 SNPs from /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.mergedReg2Map.AFR.16.annot.gz Read list of 661 individuals from /tmp/ldsc-2024-06-24-lkwISUAqN8/1000G.AFR.HM3.16.fam Reading genotypes from /tmp/ldsc-2024-06-24-lkwISUAqN8/1000G.AFR.HM3.16.bed After filtering, 36606 SNPs remain Estimating LD Score. Reading list of 1215001 SNPs for which to print LD Scores from /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt After merging with --print-snps, LD Scores for 36606 SNPs will be printed. Writing LD Scores for 36606 SNPs to /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.mergedReg2Map.AFR.16.l2.ldscore.gz Summary of LD Scores in /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.mergedReg2Map.AFR.16.l2.ldscore.gz MAF L2 mean 0.2295 1.5836 std 0.1454 2.1209 min 0.0015 -0.1109 25% 0.1029 0.3610 50% 0.2216 0.9040 75% 0.3495 1.9304 max 0.5000 23.0812 MAF/LD Score Correlation Matrix MAF L2 MAF 1.0000 0.0962 L2 0.0962 1.0000 Annotation Correlation Matrix ANNOT ANNOT 1.0 Annotation Matrix Column Sums ANNOT 5589 Summary of Annotation Matrix Row Sums count 36606.0000 mean 0.1527 std 0.3597 min 0.0000 25% 0.0000 50% 0.0000 75% 0.0000 max 1.0000 Analysis finished at Mon Jun 24 14:13:21 2024 Total time elapsed: 1.0m:24.15s Done.