Partitioning with 1000G LD scores on HapMap3 SNPs with Human_Striatum_snATAC.Oligo.hg38 bed regions making annot file Computing partitioned LD scores for hg38 for EUR. ********************************************************************* * LD Score Regression (LDSC) * Version 1.0.1 * (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane * Broad Institute of MIT and Harvard / MIT Department of Mathematics * GNU General Public License v3 ********************************************************************* Call: ./ldsc.py \ --print-snps /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt \ --out /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.Oligo.hg38.EUR.14 \ --bfile /tmp/ldsc-2024-06-24-ppTsTOBZ96/1000G.EUR.HM3.14 \ --thin-annot \ --annot /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.Oligo.hg38.EUR.14.annot.gz \ --l2 \ --ld-wind-kb 1000.0 Beginning analysis at Mon Jun 24 13:08:58 2024 Read list of 39834 SNPs from /tmp/ldsc-2024-06-24-ppTsTOBZ96/1000G.EUR.HM3.14.bim Read 1 annotations for 39834 SNPs from /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.Oligo.hg38.EUR.14.annot.gz Read list of 503 individuals from /tmp/ldsc-2024-06-24-ppTsTOBZ96/1000G.EUR.HM3.14.fam Reading genotypes from /tmp/ldsc-2024-06-24-ppTsTOBZ96/1000G.EUR.HM3.14.bed After filtering, 39834 SNPs remain Estimating LD Score. Reading list of 1215001 SNPs for which to print LD Scores from /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt After merging with --print-snps, LD Scores for 39834 SNPs will be printed. Writing LD Scores for 39834 SNPs to /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.Oligo.hg38.EUR.14.l2.ldscore.gz Summary of LD Scores in /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.Oligo.hg38.EUR.14.l2.ldscore.gz MAF L2 mean 0.2305 0.5267 std 0.1432 0.9042 min 0.0020 -0.0695 25% 0.1054 0.0194 50% 0.2177 0.1194 75% 0.3499 0.6284 max 0.5000 7.5363 MAF/LD Score Correlation Matrix MAF L2 MAF 1.0000 0.1341 L2 0.1341 1.0000 Annotation Correlation Matrix ANNOT ANNOT 1.0 Annotation Matrix Column Sums ANNOT 1056 Summary of Annotation Matrix Row Sums count 39834.0000 mean 0.0265 std 0.1606 min 0.0000 25% 0.0000 50% 0.0000 75% 0.0000 max 1.0000 Analysis finished at Mon Jun 24 13:10:15 2024 Total time elapsed: 1.0m:16.64s Done.