Partitioning with 1000G LD scores on HapMap3 SNPs with Human_Striatum_snATAC.INT.hg38 bed regions making annot file Computing partitioned LD scores for hg38 for EUR. ********************************************************************* * LD Score Regression (LDSC) * Version 1.0.1 * (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane * Broad Institute of MIT and Harvard / MIT Department of Mathematics * GNU General Public License v3 ********************************************************************* Call: ./ldsc.py \ --print-snps /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt \ --out /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.INT.hg38.EUR.2 \ --bfile /tmp/ldsc-2024-06-24-Lx27nK6ZJI/1000G.EUR.HM3.2 \ --thin-annot \ --annot /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.INT.hg38.EUR.2.annot.gz \ --l2 \ --ld-wind-kb 1000.0 Beginning analysis at Mon Jun 24 13:07:24 2024 Read list of 100669 SNPs from /tmp/ldsc-2024-06-24-Lx27nK6ZJI/1000G.EUR.HM3.2.bim Read 1 annotations for 100669 SNPs from /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.INT.hg38.EUR.2.annot.gz Read list of 503 individuals from /tmp/ldsc-2024-06-24-Lx27nK6ZJI/1000G.EUR.HM3.2.fam Reading genotypes from /tmp/ldsc-2024-06-24-Lx27nK6ZJI/1000G.EUR.HM3.2.bed After filtering, 100669 SNPs remain Estimating LD Score. Reading list of 1215001 SNPs for which to print LD Scores from /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt After merging with --print-snps, LD Scores for 100669 SNPs will be printed. Writing LD Scores for 100669 SNPs to /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.INT.hg38.EUR.2.l2.ldscore.gz Summary of LD Scores in /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.INT.hg38.EUR.2.l2.ldscore.gz MAF L2 mean 0.2367 0.6982 std 0.1439 1.0415 min 0.0020 -0.0917 25% 0.1103 0.0625 50% 0.2276 0.2667 75% 0.3598 0.9534 max 0.5000 9.1171 MAF/LD Score Correlation Matrix MAF L2 MAF 1.0000 0.1561 L2 0.1561 1.0000 Annotation Correlation Matrix ANNOT ANNOT 1.0 Annotation Matrix Column Sums ANNOT 3364 Summary of Annotation Matrix Row Sums count 100669.0000 mean 0.0334 std 0.1797 min 0.0000 25% 0.0000 50% 0.0000 75% 0.0000 max 1.0000 Analysis finished at Mon Jun 24 13:10:33 2024 Total time elapsed: 3.0m:9.47s Done.