Partitioning with 1000G LD scores on HapMap3 SNPs with Human_Striatum_snATAC.D2.Matrix.hg38 bed regions making annot file Computing partitioned LD scores for hg38 for AFR. ********************************************************************* * LD Score Regression (LDSC) * Version 1.0.1 * (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane * Broad Institute of MIT and Harvard / MIT Department of Mathematics * GNU General Public License v3 ********************************************************************* Call: ./ldsc.py \ --print-snps /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt \ --out /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.D2.Matrix.hg38.AFR.4 \ --bfile /tmp/ldsc-2024-06-24-VQ3JadhWii/1000G.AFR.HM3.4 \ --thin-annot \ --annot /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.D2.Matrix.hg38.AFR.4.annot.gz \ --l2 \ --ld-wind-kb 1000.0 Beginning analysis at Mon Jun 24 13:05:08 2024 Read list of 75316 SNPs from /tmp/ldsc-2024-06-24-VQ3JadhWii/1000G.AFR.HM3.4.bim Read 1 annotations for 75316 SNPs from /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.D2.Matrix.hg38.AFR.4.annot.gz Read list of 661 individuals from /tmp/ldsc-2024-06-24-VQ3JadhWii/1000G.AFR.HM3.4.fam Reading genotypes from /tmp/ldsc-2024-06-24-VQ3JadhWii/1000G.AFR.HM3.4.bed After filtering, 75316 SNPs remain Estimating LD Score. Reading list of 1215001 SNPs for which to print LD Scores from /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt After merging with --print-snps, LD Scores for 75316 SNPs will be printed. Writing LD Scores for 75316 SNPs to /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.D2.Matrix.hg38.AFR.4.l2.ldscore.gz Summary of LD Scores in /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.D2.Matrix.hg38.AFR.4.l2.ldscore.gz MAF L2 mean 0.2302 0.4796 std 0.1448 0.6877 min 0.0015 -0.0654 25% 0.1051 0.0691 50% 0.2194 0.2030 75% 0.3525 0.5931 max 0.5000 7.6134 MAF/LD Score Correlation Matrix MAF L2 MAF 1.0000 0.0997 L2 0.0997 1.0000 Annotation Correlation Matrix ANNOT ANNOT 1.0 Annotation Matrix Column Sums ANNOT 3462 Summary of Annotation Matrix Row Sums count 75316.0000 mean 0.0460 std 0.2094 min 0.0000 25% 0.0000 50% 0.0000 75% 0.0000 max 1.0000 Analysis finished at Mon Jun 24 13:09:37 2024 Total time elapsed: 4.0m:28.7s Done.