Partitioning with 1000G LD scores on HapMap3 SNPs with Human_Striatum_snATAC.D2.Matrix.hg38 bed regions making annot file Computing partitioned LD scores for hg38 for AFR. ********************************************************************* * LD Score Regression (LDSC) * Version 1.0.1 * (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane * Broad Institute of MIT and Harvard / MIT Department of Mathematics * GNU General Public License v3 ********************************************************************* Call: ./ldsc.py \ --print-snps /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt \ --out /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.D2.Matrix.hg38.AFR.11 \ --bfile /tmp/ldsc-2024-06-24-TrLVACzv2l/1000G.AFR.HM3.11 \ --thin-annot \ --annot /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.D2.Matrix.hg38.AFR.11.annot.gz \ --l2 \ --ld-wind-kb 1000.0 Beginning analysis at Mon Jun 24 13:05:35 2024 Read list of 61107 SNPs from /tmp/ldsc-2024-06-24-TrLVACzv2l/1000G.AFR.HM3.11.bim Read 1 annotations for 61107 SNPs from /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.D2.Matrix.hg38.AFR.11.annot.gz Read list of 661 individuals from /tmp/ldsc-2024-06-24-TrLVACzv2l/1000G.AFR.HM3.11.fam Reading genotypes from /tmp/ldsc-2024-06-24-TrLVACzv2l/1000G.AFR.HM3.11.bed After filtering, 61107 SNPs remain Estimating LD Score. Reading list of 1215001 SNPs for which to print LD Scores from /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt After merging with --print-snps, LD Scores for 61107 SNPs will be printed. Writing LD Scores for 61107 SNPs to /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.D2.Matrix.hg38.AFR.11.l2.ldscore.gz Summary of LD Scores in /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.D2.Matrix.hg38.AFR.11.l2.ldscore.gz MAF L2 mean 0.2264 0.6876 std 0.1459 1.0164 min 0.0015 -0.0606 25% 0.1006 0.0987 50% 0.2148 0.3006 75% 0.3487 0.8722 max 0.5000 12.1518 MAF/LD Score Correlation Matrix MAF L2 MAF 1.0000 0.0698 L2 0.0698 1.0000 Annotation Correlation Matrix ANNOT ANNOT 1.0 Annotation Matrix Column Sums ANNOT 3489 Summary of Annotation Matrix Row Sums count 61107.0000 mean 0.0571 std 0.2320 min 0.0000 25% 0.0000 50% 0.0000 75% 0.0000 max 1.0000 Analysis finished at Mon Jun 24 13:12:40 2024 Total time elapsed: 7.0m:5.24s Done.