Partitioning with 1000G LD scores on HapMap3 SNPs with Human_Striatum_snATAC.D1.Matrix.hg38 bed regions making annot file Computing partitioned LD scores for hg38 for AFR. ********************************************************************* * LD Score Regression (LDSC) * Version 1.0.1 * (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane * Broad Institute of MIT and Harvard / MIT Department of Mathematics * GNU General Public License v3 ********************************************************************* Call: ./ldsc.py \ --print-snps /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt \ --out /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.D1.Matrix.hg38.AFR.14 \ --bfile /tmp/ldsc-2024-06-24-HW26i3ZOGG/1000G.AFR.HM3.14 \ --thin-annot \ --annot /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.D1.Matrix.hg38.AFR.14.annot.gz \ --l2 \ --ld-wind-kb 1000.0 Beginning analysis at Mon Jun 24 13:03:48 2024 Read list of 39610 SNPs from /tmp/ldsc-2024-06-24-HW26i3ZOGG/1000G.AFR.HM3.14.bim Read 1 annotations for 39610 SNPs from /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.D1.Matrix.hg38.AFR.14.annot.gz Read list of 661 individuals from /tmp/ldsc-2024-06-24-HW26i3ZOGG/1000G.AFR.HM3.14.fam Reading genotypes from /tmp/ldsc-2024-06-24-HW26i3ZOGG/1000G.AFR.HM3.14.bed After filtering, 39610 SNPs remain Estimating LD Score. Reading list of 1215001 SNPs for which to print LD Scores from /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt After merging with --print-snps, LD Scores for 39610 SNPs will be printed. Writing LD Scores for 39610 SNPs to /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.D1.Matrix.hg38.AFR.14.l2.ldscore.gz Summary of LD Scores in /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.D1.Matrix.hg38.AFR.14.l2.ldscore.gz MAF L2 mean 0.2252 0.6574 std 0.1450 1.1329 min 0.0015 -0.0600 25% 0.0991 0.0801 50% 0.2133 0.2400 75% 0.3464 0.7769 max 0.5000 10.1931 MAF/LD Score Correlation Matrix MAF L2 MAF 1.0000 0.1163 L2 0.1163 1.0000 Annotation Correlation Matrix ANNOT ANNOT 1.0 Annotation Matrix Column Sums ANNOT 2245 Summary of Annotation Matrix Row Sums count 39610.0000 mean 0.0567 std 0.2312 min 0.0000 25% 0.0000 50% 0.0000 75% 0.0000 max 1.0000 Analysis finished at Mon Jun 24 13:06:13 2024 Total time elapsed: 2.0m:24.61s Done.