Partitioning with 1000G LD scores on HapMap3 SNPs with Human_Striatum_snATAC.merged bed regions making annot file Computing partitioned LD scores for hg38 for EUR. ********************************************************************* * LD Score Regression (LDSC) * Version 1.0.1 * (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane * Broad Institute of MIT and Harvard / MIT Department of Mathematics * GNU General Public License v3 ********************************************************************* Call: ./ldsc.py \ --print-snps /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt \ --out /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.EUR.5 \ --bfile /tmp/ldsc-2024-06-24-gOTZk7OSqB/1000G.EUR.HM3.5 \ --thin-annot \ --annot /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.EUR.5.annot.gz \ --l2 \ --ld-wind-kb 1000.0 Beginning analysis at Mon Jun 24 13:03:46 2024 Read list of 75743 SNPs from /tmp/ldsc-2024-06-24-gOTZk7OSqB/1000G.EUR.HM3.5.bim Read 1 annotations for 75743 SNPs from /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.EUR.5.annot.gz Read list of 503 individuals from /tmp/ldsc-2024-06-24-gOTZk7OSqB/1000G.EUR.HM3.5.fam Reading genotypes from /tmp/ldsc-2024-06-24-gOTZk7OSqB/1000G.EUR.HM3.5.bed After filtering, 75743 SNPs remain Estimating LD Score. Reading list of 1215001 SNPs for which to print LD Scores from /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt After merging with --print-snps, LD Scores for 75743 SNPs will be printed. Writing LD Scores for 75743 SNPs to /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.EUR.5.l2.ldscore.gz Summary of LD Scores in /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.EUR.5.l2.ldscore.gz MAF L2 mean 0.2355 2.8164 std 0.1429 3.2942 min 0.0020 -0.1826 25% 0.1103 0.7596 50% 0.2266 1.8227 75% 0.3559 3.6798 max 0.5000 33.4251 MAF/LD Score Correlation Matrix MAF L2 MAF 1.0000 0.1939 L2 0.1939 1.0000 Annotation Correlation Matrix ANNOT ANNOT 1.0 Annotation Matrix Column Sums ANNOT 10663 Summary of Annotation Matrix Row Sums count 75743.0000 mean 0.1408 std 0.3478 min 0.0000 25% 0.0000 50% 0.0000 75% 0.0000 max 1.0000 Analysis finished at Mon Jun 24 13:06:13 2024 Total time elapsed: 2.0m:27.38s Done.