Partitioning with 1000G LD scores on HapMap3 SNPs with Human_Striatum_snATAC.merged bed regions making annot file Computing partitioned LD scores for hg38 for EUR. ********************************************************************* * LD Score Regression (LDSC) * Version 1.0.1 * (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane * Broad Institute of MIT and Harvard / MIT Department of Mathematics * GNU General Public License v3 ********************************************************************* Call: ./ldsc.py \ --print-snps /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt \ --out /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.EUR.20 \ --bfile /tmp/ldsc-2024-06-24-CFT2srsyu7/1000G.EUR.HM3.20 \ --thin-annot \ --annot /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.EUR.20.annot.gz \ --l2 \ --ld-wind-kb 1000.0 Beginning analysis at Mon Jun 24 13:03:48 2024 Read list of 31383 SNPs from /tmp/ldsc-2024-06-24-CFT2srsyu7/1000G.EUR.HM3.20.bim Read 1 annotations for 31383 SNPs from /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.EUR.20.annot.gz Read list of 503 individuals from /tmp/ldsc-2024-06-24-CFT2srsyu7/1000G.EUR.HM3.20.fam Reading genotypes from /tmp/ldsc-2024-06-24-CFT2srsyu7/1000G.EUR.HM3.20.bed After filtering, 31383 SNPs remain Estimating LD Score. Reading list of 1215001 SNPs for which to print LD Scores from /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt After merging with --print-snps, LD Scores for 31383 SNPs will be printed. Writing LD Scores for 31383 SNPs to /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.EUR.20.l2.ldscore.gz Summary of LD Scores in /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.EUR.20.l2.ldscore.gz MAF L2 mean 0.2325 2.5572 std 0.1436 3.5523 min 0.0020 -0.1053 25% 0.1044 0.5645 50% 0.2207 1.4339 75% 0.3549 3.1921 max 0.5000 42.8619 MAF/LD Score Correlation Matrix MAF L2 MAF 1.0000 0.2179 L2 0.2179 1.0000 Annotation Correlation Matrix ANNOT ANNOT 1.0 Annotation Matrix Column Sums ANNOT 4452 Summary of Annotation Matrix Row Sums count 31383.0000 mean 0.1419 std 0.3489 min 0.0000 25% 0.0000 50% 0.0000 75% 0.0000 max 1.0000 Analysis finished at Mon Jun 24 13:08:43 2024 Total time elapsed: 4.0m:55.29s Done.