Partitioning with 1000G LD scores on HapMap3 SNPs with Human_Striatum_snATAC.merged bed regions making annot file Computing partitioned LD scores for hg38 for EUR. ********************************************************************* * LD Score Regression (LDSC) * Version 1.0.1 * (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane * Broad Institute of MIT and Harvard / MIT Department of Mathematics * GNU General Public License v3 ********************************************************************* Call: ./ldsc.py \ --print-snps /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt \ --out /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.EUR.19 \ --bfile /tmp/ldsc-2024-06-24-2mR3Zg6rob/1000G.EUR.HM3.19 \ --thin-annot \ --annot /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.EUR.19.annot.gz \ --l2 \ --ld-wind-kb 1000.0 Beginning analysis at Mon Jun 24 13:03:48 2024 Read list of 22710 SNPs from /tmp/ldsc-2024-06-24-2mR3Zg6rob/1000G.EUR.HM3.19.bim Read 1 annotations for 22710 SNPs from /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.EUR.19.annot.gz Read list of 503 individuals from /tmp/ldsc-2024-06-24-2mR3Zg6rob/1000G.EUR.HM3.19.fam Reading genotypes from /tmp/ldsc-2024-06-24-2mR3Zg6rob/1000G.EUR.HM3.19.bed After filtering, 22710 SNPs remain Estimating LD Score. Reading list of 1215001 SNPs for which to print LD Scores from /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt After merging with --print-snps, LD Scores for 22710 SNPs will be printed. Writing LD Scores for 22710 SNPs to /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.EUR.19.l2.ldscore.gz Summary of LD Scores in /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.EUR.19.l2.ldscore.gz MAF L2 mean 0.2363 2.1562 std 0.1431 2.3377 min 0.0020 -0.1539 25% 0.1113 0.4665 50% 0.2311 1.4163 75% 0.3559 3.0205 max 0.5000 17.2629 MAF/LD Score Correlation Matrix MAF L2 MAF 1.0000 0.1689 L2 0.1689 1.0000 Annotation Correlation Matrix ANNOT ANNOT 1.0 Annotation Matrix Column Sums ANNOT 3721 Summary of Annotation Matrix Row Sums count 22710.0000 mean 0.1638 std 0.3701 min 0.0000 25% 0.0000 50% 0.0000 75% 0.0000 max 1.0000 Analysis finished at Mon Jun 24 13:07:19 2024 Total time elapsed: 3.0m:31.08s Done.