Partitioning with 1000G LD scores on HapMap3 SNPs with Human_Striatum_snATAC.merged bed regions making annot file Computing partitioned LD scores for hg38 for EUR. ********************************************************************* * LD Score Regression (LDSC) * Version 1.0.1 * (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane * Broad Institute of MIT and Harvard / MIT Department of Mathematics * GNU General Public License v3 ********************************************************************* Call: ./ldsc.py \ --print-snps /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt \ --out /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.EUR.12 \ --bfile /tmp/ldsc-2024-06-24-afGgXvkh8z/1000G.EUR.HM3.12 \ --thin-annot \ --annot /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.EUR.12.annot.gz \ --l2 \ --ld-wind-kb 1000.0 Beginning analysis at Mon Jun 24 13:03:48 2024 Read list of 59167 SNPs from /tmp/ldsc-2024-06-24-afGgXvkh8z/1000G.EUR.HM3.12.bim Read 1 annotations for 59167 SNPs from /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.EUR.12.annot.gz Read list of 503 individuals from /tmp/ldsc-2024-06-24-afGgXvkh8z/1000G.EUR.HM3.12.fam Reading genotypes from /tmp/ldsc-2024-06-24-afGgXvkh8z/1000G.EUR.HM3.12.bed After filtering, 59167 SNPs remain Estimating LD Score. Reading list of 1215001 SNPs for which to print LD Scores from /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt After merging with --print-snps, LD Scores for 59167 SNPs will be printed. Writing LD Scores for 59167 SNPs to /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.EUR.12.l2.ldscore.gz Summary of LD Scores in /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.EUR.12.l2.ldscore.gz MAF L2 mean 0.2312 2.8424 std 0.1440 3.1604 min 0.0020 -0.1676 25% 0.1054 0.8107 50% 0.2177 1.8849 75% 0.3549 3.7351 max 0.5000 32.1816 MAF/LD Score Correlation Matrix MAF L2 MAF 1.0000 0.1596 L2 0.1596 1.0000 Annotation Correlation Matrix ANNOT ANNOT 1.0 Annotation Matrix Column Sums ANNOT 8735 Summary of Annotation Matrix Row Sums count 59167.0000 mean 0.1476 std 0.3547 min 0.0000 25% 0.0000 50% 0.0000 75% 0.0000 max 1.0000 Analysis finished at Mon Jun 24 13:05:43 2024 Total time elapsed: 1.0m:55.5s Done.