Partitioning with 1000G LD scores on HapMap3 SNPs with Human_Striatum_snATAC.merged bed regions making annot file Computing partitioned LD scores for hg38 for AFR. ********************************************************************* * LD Score Regression (LDSC) * Version 1.0.1 * (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane * Broad Institute of MIT and Harvard / MIT Department of Mathematics * GNU General Public License v3 ********************************************************************* Call: ./ldsc.py \ --print-snps /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt \ --out /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.AFR.3 \ --bfile /tmp/ldsc-2024-06-24-oziJEFHAOG/1000G.AFR.HM3.3 \ --thin-annot \ --annot /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.AFR.3.annot.gz \ --l2 \ --ld-wind-kb 1000.0 Beginning analysis at Mon Jun 24 13:03:46 2024 Read list of 83630 SNPs from /tmp/ldsc-2024-06-24-oziJEFHAOG/1000G.AFR.HM3.3.bim Read 1 annotations for 83630 SNPs from /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.AFR.3.annot.gz Read list of 661 individuals from /tmp/ldsc-2024-06-24-oziJEFHAOG/1000G.AFR.HM3.3.fam Reading genotypes from /tmp/ldsc-2024-06-24-oziJEFHAOG/1000G.AFR.HM3.3.bed After filtering, 83630 SNPs remain Estimating LD Score. Reading list of 1215001 SNPs for which to print LD Scores from /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt After merging with --print-snps, LD Scores for 83630 SNPs will be printed. Writing LD Scores for 83630 SNPs to /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.AFR.3.l2.ldscore.gz Summary of LD Scores in /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.AFR.3.l2.ldscore.gz MAF L2 mean 0.2302 1.6271 std 0.1468 2.0444 min 0.0015 -0.0776 25% 0.1029 0.4358 50% 0.2201 1.0256 75% 0.3555 2.0573 max 0.5000 26.7159 MAF/LD Score Correlation Matrix MAF L2 MAF 1.0000 0.1458 L2 0.1458 1.0000 Annotation Correlation Matrix ANNOT ANNOT 1.0 Annotation Matrix Column Sums ANNOT 11752 Summary of Annotation Matrix Row Sums count 83630.0000 mean 0.1405 std 0.3475 min 0.0000 25% 0.0000 50% 0.0000 75% 0.0000 max 1.0000 Analysis finished at Mon Jun 24 13:06:53 2024 Total time elapsed: 3.0m:6.82s Done.