Partitioning with 1000G LD scores on HapMap3 SNPs with Human_Striatum_snATAC.merged bed regions making annot file Computing partitioned LD scores for hg38 for AFR. ********************************************************************* * LD Score Regression (LDSC) * Version 1.0.1 * (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane * Broad Institute of MIT and Harvard / MIT Department of Mathematics * GNU General Public License v3 ********************************************************************* Call: ./ldsc.py \ --print-snps /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt \ --out /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.AFR.21 \ --bfile /tmp/ldsc-2024-06-24-MopYnUoTEC/1000G.AFR.HM3.21 \ --thin-annot \ --annot /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.AFR.21.annot.gz \ --l2 \ --ld-wind-kb 1000.0 Beginning analysis at Mon Jun 24 13:03:35 2024 Read list of 17085 SNPs from /tmp/ldsc-2024-06-24-MopYnUoTEC/1000G.AFR.HM3.21.bim Read 1 annotations for 17085 SNPs from /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.AFR.21.annot.gz Read list of 661 individuals from /tmp/ldsc-2024-06-24-MopYnUoTEC/1000G.AFR.HM3.21.fam Reading genotypes from /tmp/ldsc-2024-06-24-MopYnUoTEC/1000G.AFR.HM3.21.bed After filtering, 17085 SNPs remain Estimating LD Score. Reading list of 1215001 SNPs for which to print LD Scores from /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt After merging with --print-snps, LD Scores for 17085 SNPs will be printed. Writing LD Scores for 17085 SNPs to /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.AFR.21.l2.ldscore.gz Summary of LD Scores in /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.AFR.21.l2.ldscore.gz MAF L2 mean 0.2291 1.2088 std 0.1449 1.4724 min 0.0015 -0.0765 25% 0.1036 0.2540 50% 0.2194 0.6709 75% 0.3510 1.6208 max 0.5000 11.7041 MAF/LD Score Correlation Matrix MAF L2 MAF 1.0000 0.0928 L2 0.0928 1.0000 Annotation Correlation Matrix ANNOT ANNOT 1.0 Annotation Matrix Column Sums ANNOT 2308 Summary of Annotation Matrix Row Sums count 17085.0000 mean 0.1351 std 0.3418 min 0.0000 25% 0.0000 50% 0.0000 75% 0.0000 max 1.0000 Analysis finished at Mon Jun 24 13:04:14 2024 Total time elapsed: 39.85s Done.