Partitioning with 1000G LD scores on HapMap3 SNPs with Human_Striatum_snATAC.merged bed regions making annot file Computing partitioned LD scores for hg38 for AFR. ********************************************************************* * LD Score Regression (LDSC) * Version 1.0.1 * (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane * Broad Institute of MIT and Harvard / MIT Department of Mathematics * GNU General Public License v3 ********************************************************************* Call: ./ldsc.py \ --print-snps /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt \ --out /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.AFR.15 \ --bfile /tmp/ldsc-2024-06-24-BilEeVLpPt/1000G.AFR.HM3.15 \ --thin-annot \ --annot /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.AFR.15.annot.gz \ --l2 \ --ld-wind-kb 1000.0 Beginning analysis at Mon Jun 24 13:03:35 2024 Read list of 35905 SNPs from /tmp/ldsc-2024-06-24-BilEeVLpPt/1000G.AFR.HM3.15.bim Read 1 annotations for 35905 SNPs from /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.AFR.15.annot.gz Read list of 661 individuals from /tmp/ldsc-2024-06-24-BilEeVLpPt/1000G.AFR.HM3.15.fam Reading genotypes from /tmp/ldsc-2024-06-24-BilEeVLpPt/1000G.AFR.HM3.15.bed After filtering, 35905 SNPs remain Estimating LD Score. Reading list of 1215001 SNPs for which to print LD Scores from /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt After merging with --print-snps, LD Scores for 35905 SNPs will be printed. Writing LD Scores for 35905 SNPs to /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.AFR.15.l2.ldscore.gz Summary of LD Scores in /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.AFR.15.l2.ldscore.gz MAF L2 mean 0.2309 1.4822 std 0.1469 1.7692 min 0.0015 -0.0974 25% 0.1021 0.3302 50% 0.2209 0.8847 75% 0.3563 1.9573 max 0.5000 15.1462 MAF/LD Score Correlation Matrix MAF L2 MAF 1.0000 0.0952 L2 0.0952 1.0000 Annotation Correlation Matrix ANNOT ANNOT 1.0 Annotation Matrix Column Sums ANNOT 5062 Summary of Annotation Matrix Row Sums count 35905.000 mean 0.141 std 0.348 min 0.000 25% 0.000 50% 0.000 75% 0.000 max 1.000 Analysis finished at Mon Jun 24 13:04:57 2024 Total time elapsed: 1.0m:22.38s Done.