Partitioning with 1000G LD scores on HapMap3 SNPs with Human_Striatum_snATAC.merged bed regions making annot file Computing partitioned LD scores for hg38 for AFR. ********************************************************************* * LD Score Regression (LDSC) * Version 1.0.1 * (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane * Broad Institute of MIT and Harvard / MIT Department of Mathematics * GNU General Public License v3 ********************************************************************* Call: ./ldsc.py \ --print-snps /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt \ --out /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.AFR.12 \ --bfile /tmp/ldsc-2024-06-24-r8WosorSA0/1000G.AFR.HM3.12 \ --thin-annot \ --annot /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.AFR.12.annot.gz \ --l2 \ --ld-wind-kb 1000.0 Beginning analysis at Mon Jun 24 13:03:46 2024 Read list of 58816 SNPs from /tmp/ldsc-2024-06-24-r8WosorSA0/1000G.AFR.HM3.12.bim Read 1 annotations for 58816 SNPs from /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.AFR.12.annot.gz Read list of 661 individuals from /tmp/ldsc-2024-06-24-r8WosorSA0/1000G.AFR.HM3.12.fam Reading genotypes from /tmp/ldsc-2024-06-24-r8WosorSA0/1000G.AFR.HM3.12.bed After filtering, 58816 SNPs remain Estimating LD Score. Reading list of 1215001 SNPs for which to print LD Scores from /projects/pfenninggroup/machineLearningForComputationalBiology/gwasEnrichments/1000G_EUR_Phase3_GRCh38_files/hapmap3_snps/listHM3.noMHC.txt After merging with --print-snps, LD Scores for 58816 SNPs will be printed. Writing LD Scores for 58816 SNPs to /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.AFR.12.l2.ldscore.gz Summary of LD Scores in /projects/pfenninggroup/machineLearningForComputationalBiology/StriatumComparativeGenomics/data/tidy_data/human_Str_ldsc/annotations/Human_Striatum_snATAC.merged.AFR.12.l2.ldscore.gz MAF L2 mean 0.2203 1.5938 std 0.1474 1.8142 min 0.0015 -0.1263 25% 0.0915 0.4288 50% 0.2073 1.0651 75% 0.3442 2.0942 max 0.5000 22.1597 MAF/LD Score Correlation Matrix MAF L2 MAF 1.0000 0.1153 L2 0.1153 1.0000 Annotation Correlation Matrix ANNOT ANNOT 1.0 Annotation Matrix Column Sums ANNOT 8660 Summary of Annotation Matrix Row Sums count 58816.0000 mean 0.1472 std 0.3543 min 0.0000 25% 0.0000 50% 0.0000 75% 0.0000 max 1.0000 Analysis finished at Mon Jun 24 13:05:58 2024 Total time elapsed: 2.0m:11.46s Done.